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Natto is widely recognized for inhibiting arteriosclerosis, yet its underlying mechanism remains elusive. Researchers led by the University of Tsukuba studied the effects of natto on arteriosclerosis in mice. The findings showed that consuming natto induced changes in the intestinal microflora, suppressing inflammation and preventing arteriosclerosis.

Tsukuba, Japan—Atherosclerosis, a chronic condition characterized by the accumulation of lipid and inflammatory cells within the blood vessel walls, causes cardiovascular diseases, such as heart disease and stroke. Natto, a food rich in vitamin K2, has shown promise in mitigating cardiovascular diseases by enhancing arterial flexibility and modulating inflammatory responses. However, the reason why natto suppresses arteriosclerosis remains elusive.

This study employed three varieties of natto distinguished by their vitamin K2 content--namely, high vitamin K2, normal, and low vitamin K2 natto. The research team systematically assessed the impact of natto on atherosclerosis in a mouse model over time. The findings revealed a significant reduction in atherosclerotic lesions across all natto consumption groups. Furthermore, the intake of natto altered the composition of intestinal microflora, regulating the production of cytokines and chemokines associated with arteriosclerosis. This suggests that incorporating natto into the diet may have a therapeutic effect on arteriosclerosis. Additionally, the study uncovered that adding Bacillus subtilis natto to macrophages, a cell type implicated in promoting arteriosclerosis, decreased pro-inflammatory cytokines and chemokines. The effect was particularly significant with high vitamin K2 natto consumption group. Moreover, both regular and low vitamin K2 natto increased the production of the anti-inflammatory cytokine IL-10. These findings indicate that Bacillus subtilis natto, aside from its role as an intestinal bacterium, may inhibit atherosclerosis by altering the intestinal microflora and suppressing the activation of immune cells.

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This work was supported by MEXT/JSPS KAKENHI (19K05926 to Y. H.); and the World Premier International Research Center Initiative (WPI), MEXT, Japan.

Original Paper

Title of original paper:

Natto consumption suppresses atherosclerotic plaque progression in LDL receptor deficient mice transplanted with iRFP-expressing hematopoietic cells

Journal:

Scientific Reports

DOI:

10.1038/s41598-023-48562-y

Correspondence

Professor HIRAMATSU Yuji
Institute of Medicine, University of Tsukuba

KAWAMATA Takeshi
Doctoral Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba

NISHIKAWA Takanobu
Department of Natto Research and Development, Takanofoods Corporation

Related Link

Institute of Medicine